The science behind lipolysis and the topics being researched in the field.
- Lipolysis – the body’s breakdown of fat
- Mechanisms beyond lipolysis
Lipolysis – the body’s breakdown of fat
Fat burning in research is about lipolysis: how fat cells release fatty acids. HGH Frag 176-191 and AOD-9604 are fragments of growth hormone that have been studied for this particular mechanism.
Mechanisms beyond lipolysis
5-AMINO-1MQ is being studied for the enzyme NNMT and MOTS-c for mitochondrial energy metabolism – two other avenues into the same research field.
The list
The list is editorial and is based on how often the substances appear in research – not on proven efficacy or safety in humans.
The difference between potential and evidence
Always review safety, study size, control groups, and whether the results have been replicated. Be especially wary of claims that promise quick or guaranteed effects.
Sources and further reading
We refer to published research and authorities. Research results do not mean that a substance is safe or approved for humans.
- 01
Current research on AOD-9604PubMed (NIH)Search in the scientific database PubMed – compiles published studies.
- 02
Current research on 5-AMINO-1MQ and NNMTPubMed (NIH)Search in the scientific database PubMed – compiles published studies.
- 03
Triple–Hormone-Receptor Agonist Retatrutide for ObesityNew England Journal of Medicine, 2023Phase 2 study of retatrutide. The molecule is not approved as a drug.
- 04
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)New England Journal of Medicine, 2021Phase 3 clinical trial of semaglutide.
- 05
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)New England Journal of Medicine, 2022Phase 3 clinical study of tirzepatide.
- 06
Current research on MOTS-cPubMed (NIH)Search in the scientific database PubMed – compiles published studies.